how dopamine works in human brain: its receptors and examples

DOPAMINE

Introduction:

                       Dopamine is a neuromodulator molecule that paly several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine family. Dopamine constitutes about 80% of the catecholamine content in the brain.

                                                        MAIN BODY

The way that your body uses dopamine is to have a baseline level of dopamine, meaning an amount of Dopamine that’s calculating all the turns out to be important for how you feel generally, whether or not you are in good mood, motivated etc.

You also experience peaks in Dopamine above baseline. So-called tonic and phasic release of dopamine, these peaks in dopamine they influence how much dopamine will generally be circulating afterward. And you might think, oh! A big peak in dopamine after that. I am going to feel even better because I just had this great event. Not the case!

What actually happens is that your baseline level of dopamine drops.

TONIC

Tonic being the lower-level baseline that always there circulating, released in your brain all the time, and then PHASIC, these peaks that ride above that base line, and those two things interact and is really important.

Dopamine has everything to do with how you feel right now, it has everything to do with how would you feel an hour from now, has everything to do with your level of motivation.

Here some examples to understand the importance and power of Dopamine. get more information athttps://yubloger.com/

DRUGS AND DOPAMINE:

In a healthy person, the reward system reinforces important behavior that are essential for survival such as feeding, sexual activity and social interaction.

For Example; the reward system ensures that you reach for food when you are hungry, because you know that after eating you feel good. In other word it makes the activity of eating pleasurable and measurable. so, you would want to do it again and again whenever you feel hungry. Similarly!

Drugs of abuse hijack this system. Turning the person’s natural needs into drugs need. The brain consists of billions of nerve cells or neurons, which communicates via chemical messages or neurotransmitters. When a neuron is sufficiently simulated an electrical impulse called an action potential is generated a travel down the exon to the nerve terminal.

Here it triggers the release of neurotransmitters into the synaptic cleft, a space between neurons.

NEUROTRANSMITTERS

The neurotransmitters then bind to a receptor on a neighboring neuron, generating a signal in it. Thereby transmitting the information to that neuron. The major reward pathways involved the transmission of a neurotransmitters called dopamine from the ventral tag mental are the VTA of the mid brain, to the limbic system and the frontal cortex.

LOVE AND DOPAMINE

                                           Why love is addictive? Love makes us joyful, obsessive, sometime sick and addictive drugs do the same thing but, why is love is powerful drug?

Love and addictive drugs share the same progression the initial euphoric honeymoon period drawn out stage of constant usage gradually building up a tolerance. Its all just because of Dopamine that release in our brain.

POWER OF DOPAMINE

Some facts about the structure of dopamine are:

1. Molecular structure: C₈H₁₁NO₂
2. Where produced: Many brain reigns.
3. Control: pleasure, emotions, movement, motivation, cognition.
4. Too much: overload of pleasure, depression, emotional.
5. Activities that boost levels: having healthy relationships.

DOPAMINE RECEPTORS

D1 like receptors -Gas- coupled  -simulated AC   -increase in CAMP   Dopamine D1 Receptor[D1R]     Dopamine D5 Receptor[D5R]

D2-like receptors -Ga1/ Ga0 – coupled  -inhibits AC   -Decrease in CAMP   Dopamine D2 Receptor[D2R]     Dopamine D3 Receptor[D3R]     Dopamine D4 Receptor[D4R]